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Toxicological advice indicate treatment with Activated Charcoal (AC (aka Activated Carbon)) for moderately severe to life-threatening poisonings by “eliminating the toxic capability of hazardous substances”. AC is on the WHO Model List of Essential Medicines and is one of the standard antidotes EMS workers should always have on hand. Objectives state the need for stockpiling as intoxication is widely common with as many causes as there are toxins. AC absorbs many noxious substances onto its surface, preventing their absorption from the gastrointestinal tract. As a secondary decontamination mechanism, it interrupts a potential enterohepatic (Enterohepatic circulation [EC] refers to the circulation of acids, drugs or other substances from the liver to the bile, followed by entry into the small intestine and back to the liver. EC is especially important in toxicology this repeated process causes liver damage.) and/or enteroenteric circulation (Enteroenteric circulation is the secretion of substances back into the intestines. It occurs when there is a concentration of substance in the intestines, making it passively diffuse into the trapped intestinal lumen.)Check source article for substances that bind adequately to carbon.

Repeat/multi-dosing is recommended for long term exposure because:

  • Toxins are eliminated even in distal sections of the gastrointestinal tract. 2. Is secondary elimination of toxins (aka: “gastrointestinal dialysis”) both of which are interrupted by activated charcoal: toxins can diffuse out of the blood and onto the charcoal and its efficacy has been demonstrated both clinically and experimentally. Administration of activated charcoal against the express will of the patient, whether an adult or a minor, is justified only in the event of a life-threatening intoxication. In the case of a life-threatening suicide attempt, forced administration of activated charcoal via a stomach tube can be considered even against the patient’s will.

 

Fullerenes as a treatment of cancer is a tool to fight a far too common cause of global mortality. Available medicines have severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. C60 possesses interesting photo-physical properties and generates reactive oxygen species (ROS) by exposure to visible light, giving it strong potential for photodynamic therapy (PDT). The specific physicochemical properties of fullerenes promoted the development of tumor theranostic; consequently, functionalized fullerenes are currently under extensive investigation and some keyword takeaways: “tumor targeted” ; “acoustic-explosion” after exposure ; induce carcinoma cell death ; induce apoptosis ; efficiently inhibit the growth with low toxicity; reverse tumor resistance… Nanotechnology (the branch of technology that deals with dimensions, nanometers, and especially the manipulation of atoms and molecules) has changed the game for cancer diagnosis and therapy. The traditional approaches are highly intrusive, non-specific, and typically associated with tumor and solid cell damage. Fullerene derivatives have been demonstrated in studies to exhibit a wide range of anti-tumor properties, including immunological boosting, anti-oxidation, anti-metastasis, cell cycle arrest, tumor angiogenesis suppression , just some of the routes taken by the carbon nanocarriers to reach the target tumor tissues with their intriguing optical, electrical, and magnetic characteristics.

 

WARNING: These statements have NOT been evaluated by the FDA. Never stop any routine medical care without consulting with your physician first.

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